You can use this VST: https://www.kvraudio.com/product/vopm-by-sam You will need some .opm files which basically are the instruments from various Genesis games including the Sonic ones. Here's a link to that: http://truechiptilldeath.com/blog/2010/05/04/opm-patches-out-of-most-genesis-games/
Speaking of Sega sounds, I recently found a VST that emulates some of the ones from the Sega Master System: https://bedroomproducersblog.com/2017/08/09/sn76489-vst/ might be worth a look for people interested in this stuff.
Also the best program for converting the VGM files from Sonic and other Sega games to midi is v2m05src. Unfortunately it still has a problem with accurately ripping drums/percussion notes but everything else works fine.
by birdmanager6 at 2:42 PM EDT on October 14, 2017